Usizo olubalulekile ekwandeni kobuKristu eMakedoniya kwakuyi-Via Egnatia, umgwaqo omkhulu wamaRoma ogandaywe ngamatshe. Ngemva kokufika ethekwini laseNeyapholi (manje eliyiKaválla, eGreece) enyakatho ye-Aegean Sea, kubonakala sengathi lezi zithunywa zevangeli zahamba ngalowo mgwaqo omkhulu zilibangise eFilipi, inhloko-dolobha yesifunda saseMakedoniya. Lomgwaqo wawudlulela e-Amfipholi, e-Apholoniya naseThesalonika, izindawo uPawulu nabangane bakhe abaya kuzo ngokulandelayo.—IzEnzo 16:11–17:1.

Nokho, i-Via Egnatia yalethela abantu abahlala kulendawo inzuzo ephakeme kakhulu kunokuchuma ngokwezinto ezibonakalayo. Ngokwesibonelo, cabanga ngowesifazane owayengusomabhizinisi owayechuma uLidiya. Wayehlala eFilipi—umuzi wokuqala eYurophu owezwa uPawulu eshumayela izindaba ezinhle. Ngemva kokufika eNeyapholi ngo-50 C.E., umphostoli uPawulu nabangane bakhe bahamba amakhilomitha angu-16 beya enyakatho-ntshonalanga eFilipi besebenzisa i-Via Egnatia.